A client will be receiving lepirudin (Refludan). Which of the following is true concerning this drug

A client will be receiving lepirudin (Refludan). Which of
the following is true concerning this drug therapy? Select all that apply.

1. Ginger, garlic, and green tea may increase the risk of
bleeding. 2. Vitamin B 12 is used to augment this drug’s response. 3. Refludan
is used for heparin-induced thrombocytopenia. 4. Activated partial
thromboplastin time is monitored to determine effectiveness. 5. This drug is
contraindicated for clients with severe hypertension.