Insulin and glucagon release from the pancreas is a vital part of the negative feedback loop…

Insulin and glucagon release from the pancreas is a vital part
of the negative feedback loop that regulates blood glucose levels.
Let’s review how insulin and glucagon release change in response to
plasma glucose levels and how that helps keep plasma glucose
constant.

Drag the labels onto the figure to create a flow chart of how
insulin and glucagon release change in different circumstances to
keep blood glucose within a normal range.

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secrete less glucagon
secrete less glucagon
Decreased plasma glucose
Decreased plasma glucose
release stored glucose
release stored glucose
secrete more glucagon
secrete more glucagon
Increased glucose uptake
Increased glucose uptake
secrete less insulin
secrete less insulin
secrete more insulin
secrete more insulin
Increased plasma glucose
Increased plasma glucose

† Plasma glucose Plasma glucose Beta cells in pancreas Alpha cells in pancreas Negative feedback Negative feedback 1 Insulin secretion 1 Glucagon secretion . . . . . . . . . . Most tissues Liver and muscle Liver Liver Adipose tissue . . . Gluconeogenesis . 1 Glycogen synthesis 1 Gluconeogenesis 1 Glucose uptake into cells † Lipolysis . . † Glycogenolysis . Glycogenolysis . . † Plasma fatty acids . . I I I Plasma glucose 1 Plasma glucose Glucose spared 0 Initial stimulus Physiological response Result 0 (a) (b) 1 Plasma glucose Plasma glucose beta cells alpha cells beta cells alpha cells Negative feedback TEH Most cells Most cells